Attempt by security transparent method 'WebMatrix.WebData.PreApplicationStartCode.Start()' ? 

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Why I get the following error at begin running VS.NET 2015 debug IIS :

Attempt by security transparent method 'WebMatrix.WebData.PreApplicationStartCode.Start()' to access security critical method 'System.Web.WebPages.Razor.WebPageRazorHost.AddGlobalImport(System.String)' failed

 

It seem to you don't have Microsoft.AspNET.WebHelpers installed after updating from MVC4 to MVC5. 

Install-Package Microsoft.AspNET.WebHelpers